The endophenotype and the phenotype: Temporal discrimination and adult-onset dystonia

Year
2013
Type(s)
Author(s)
Hutchinson, Michael and Kimmich, Okka and Molloy, Anna and Whelan, Robert and Molloy, Fiona and Lynch, Tim and Healy, Daniel G and Walsh, Cathal and Edwards, Mark J and Ozelius, Laurie and others
Source
Movement Disorders, 28(13): 1766—1774, 2013
Url
http://onlinelibrary.wiley.com/doi/10.1002/mds.25676/full

The pathogenesis and the genetic basis of adult-onset primary torsion dystonia remain poorly understood. Because of markedly reduced penetrance in this disorder, a number of endophenotypes have been proposed; many of these may be epiphenomena secondary to disease manifestation. Mediational endophenotypes represent gene expression; the study of trait (endophenotypic) rather than state (phenotypic) characteristics avoids the misattribution of secondary adaptive cerebral changes to pathogenesis. We argue that abnormal temporal discrimination is a mediational endophenotype; its use facilitates examination of the effects of age, gender, and environment on disease penetrance in adult-onset dystonia. Using abnormal temporal discrimination in unaffected first-degree relatives as a marker for gene mutation carriage may inform exome sequencing techniques in families with few affected individuals. We further hypothesize that abnormal temporal discrimination reflects dysfunction in an evolutionarily conserved subcortical-basal ganglia circuit for the detection of salient novel environmental change. The mechanisms of dysfunction in this pathway should be a focus for future research in the pathogenesis of adult-onset primary torsion dystonia.